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MARC - UT Health San Antonio Click for information

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Mays Cancer Center at UT Health  Click for information

Ruthe B. Cowl Rehabilitation Center, Laredo, TX  Click for information

Palladino, Michael G., DPM, FACFAS

Palladino, Michael G. , DPM, FACFAS
Assistant Professor, Chief of Podiatry
Director, Podiatric Surgical Residency Program

Dr. Palladino joined the Department of Orthopaedics as a faculty member in June 2009. Currently he is an Assistant Professor, Chief of Podiatry and the Podiatric Residency Program Director within the Division of Podiatric Medicine & Surgery at UTHSCSA.

Dr. Palladino completed his surgical residency at Northlake Community Hospital in Chicago, Illinois in 1981. After being in private practice for nineteen years, Dr. Palladino served as the associate residency director at the Yale / VA Podiatric Surgical Residency Program in New Haven, Connecticut from 2001-2006. He was then offered the position of Research Director at the North American Center for Limb Preservation where he was involved with clinical trials dealing with antibiotics, investigational topical drugs and medical devices for the treatment of diabetic foot wounds.

Dr. Palladino’s interests lie in the areas of resident teaching, education and clinical research involving the diabetic foot. He is Board Certified in Foot and Ankle Surgery and is a Fellow of the American College of Foot and Ankle Surgeons.

 Research Projects

Ongoing Research


Fukuda Denshi U.S.A., Inc.                         Palladino (PI)                                             07/2015-present

CAVI Healthy Subject Data Collection with Latino Heritage Analysis

The goals of this study are: 1) To collect cardio-ankle vascular index (CAVI), arterial dynamics, and basic demographic data on healthy Americans in a cross sectional study; and 2) To determine whether there is a difference in healthy baseline CAVI values between the Latino and non-Latino study participants.

Role: Principal Investigator

MR3 Health, Inc.                                           Palladino (PI)                                                12/2015-present

Home temperature monitoring and management of patients with a history of diabetic foot ulcers to reduce cost of care

The goal of this study is to demonstrate the clinical and cost effectiveness of home foot temperature monitoring of patients with a history of diabetic foot ulcers when combined with weekly contacts with a nurse to increase compliance.

Role: Principal Investigator

Amniox Medical, Inc.                                        Palladino (PI)                                           04/2016-present

A Multi-center, Randomized, Controlled Trial of Non-healing Diabetic Foot Ulcers (DFU) Treated with Standard of Care with or without Cryopreserved Umbilical Cord Allograft (NEOX® CORD 1KTM)

The goal of this study is to observe the safety of NEOX® CORD 1K™ in patients with non-healing diabetic foot ulcers.

Role: Principal Investigator

Rochal Industries, LLC                             Palladino (PI)                                               01/2017-Present

Preliminary Efficacy and Safety Trial of Atteris Products for the Treatment of Chronic Diabetic Foot Ulcers. This is a first-in-humans pilot of the combination of two wound care products with antimicrobial capability: Atteris Antimicrobial Skin & Wound Cleanser (AWC) and Atteris Antimicrobial Barrier Film Dressing (ABF).

The goal of this study is to determine whether the combination of AWC and ABF can safely promote healing of chronic foot ulcers in diabetic  patients.

Role: Principal Investigator

Completed Research


Integra LifeSciences Corporation             Palladino (PI)                                               10/2010-04/2014

A Multi-Center, Randomized, Controlled Clinical Trial to Evaluate the Safety and Effectiveness of Integra® Dermal Regeneration Template for the Treatment of Neuropathic Diabetic Foot Ulcers.

The goal of this study is to evaluate the safety and effectiveness of the Integra® Dermal Regeneration Template for the treatment of diabetic foot ulcers in subjects with diabetes mellitus, neuropathy, and without significantly compromised arterial circulation.

Role: Principal Investigator

Electrochemical Oxygen Concepts             Palladino (PI)                                                    04/2013-09/2016      

A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen (CDO) Therapy to standard Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Ulcers

The goals of this study are: 1) to evaluate the effectiveness of CDO in combination with standard moist wound therapy (MWT) on wound healing as compared to standard MWT alone; and 2) screening for potential safety issues.

Role: Principal Investigator