Dr. Fajardo and colleagues at Harvard Medical School published a review article in the Journal of Bone and Mineral Research highlighting the need to develop new mouse/rat models of type 2 diabetes (T2D) for studies of diabetic skeletal fragility. Slowly, biomedical researchers have begun to understand that T2D also leads to increased fracture risk in adults. This is an important area for new research because over 20 million adults in the United States have T2D. This issue is particularly relevant for San Antonio and its Hispanic population since the prevalence of T2D is high.
This review, the first of its kind, critically reviews the literature and indicates that while animal models replicate many of the skeletal effects of T2D in humans, none do so adequately at this time. Moreover, the work highlights many knowledge gaps about the underlying causes of fractures in human T2D.
The article can be found at the JBMR website: (This will open a new browser window.)
The article has been selected as an Editor’s Choice publication for the month of May.